skip to Main Content
S-Adenosylmethionine – What Is It?

S-Adenosylmethionine – what is it?

S-Adenosylmethionine is formed by the methylation of methionine in our cells. It plays a role in the immune system, maintains cell membranes and helps produce and break down brain chemicals such as dopamine melatonin and serotonin.

Key takeaways: 

1. S-Adenosylmethionine is formed in our body by the methylation of methionine.

2. It is recommended to eat foods rich in folate (green leafy vegetables, fruits, nuts and beans especially) to increase the concentration of s-adenosylmethionine.

3. Studies found that it can help treat depression, improve neurological function, reduce inflammation and alleviate pain from osteoarthritis.


What is S-Adenosylmethionine? 

S-Adenosylmethionine (SAM-e) plays a large part in DNA modifications, repairing of mismatched base pairs, histone modifications, and more, so it has been a topic of interest for those studying cancer and diseases. It was found that SAM-e can be metabolised if it is taken orally, so it is available to the public in supplement form. SAM-e is also more abundant when people incorporate folates into their diet, so it is recommended that one eats vegetables (especially green and leafy ones), fruits, nuts, and beans.


Why is it important to our health? 

SAM-e depletion can occur for several reasons, such as alcohol abuse, genetic factors, and lack of folates in one’s diet. SAM-e can be used to treat various conditions, because of its importance in many physiological processes. SAM-e has the capability of restoring depleted glutathione reserves in people who have cirrhosis, hepatitis, and other liver diseases. It has also been shown that SAM-e can help to treat depression because lack of SAM-e, a result of low folate and B-12 intake, is related to decreased release of serotonin, acetylcholine, and dopamine. SAM-e also improves neurological function, and because it reduces inflammation, it can also alleviate pain from osteoarthritis.



Works Cited 

Bottiglieri, Teodoro. “Folate, vitamin B12, and S-adenosylmethionine.” Psychiatric Clinics 36.1 (2013): 1-13.

Chiang, Peter K., et al. “S-Adenosylmethionine and methylation.” The FASEB journal 10.4 (1996): 471-480.

Lieber, Charles S., and Lester Packer. “S-Adenosylmethionine: molecular, biological, and clinical aspects—an introduction.” The American journal of clinical nutrition 76.5 (2002): 1148S-1150S.

Loenen, W. A. M. “S-adenosylmethionine: jack of all trades and master of everything?.” (2006): 330-333.

Papakostas, George I., et al. “S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial.” American Journal of Psychiatry 167.8 (2010): 942-948.

Sabina, Alyse. “S-adenosylmethionine (SAMe) as treatment for depression: a systematic review.” About CSCI 28.3 (2005): 132-139.

Teodoro Bottiglieri, S-Adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule, The American Journal of Clinical Nutrition, Volume 76, Issue 5, November 2002, Pages 1151S–1157S,

Back To Top